The Zlotnick lab dissects virus assembly using a broad array of biophysical and biochemical tools. We perturb “normal” assembly with mutants and small molecules. Results of perturbations are observed in vitro and in cells. Changes in structure are correlated with changes in assembly.
Assembly-directed small molecules can be antivirals. Our small molecules speed up assembly by orders of magnitude. How can this be antiviral? Imagine an assembly line, producing cars or viruses. It moves at a relatively slow rate and different pieces are added one at a time. If we accelerate the assembly line a little bit, say twofold, we get more cars but also more mistakes. If we accelerate the assembly line 100-fold, say from ¼ mile and hour to 25 miles an hour, we’ll be lucky to get a steering wheel.
Recent News
Congratulations to Adam Zlotnick for being named Distinguished Professor!
We have our own celebrity . . . 3 faculty named Distinguished Professors - Indiana University has named three faculty members as Distinguished Professors, the most prestigious appointment offered to honor faculty whose outstanding scholarship, artistic or literary distinction or other achievements have won significant recognition by peers. Read the article here: https://today.iu.edu/live/news/4487-3-faculty-named-distinguished-professors
Nora Gibes receives Peglow Award for International HBV Meeting
Congratulations to Nora Gibes! She is the recipient of a Peglow Award for travel to the 2022 International HBV Meeting in Paris, France from September 18-22, 2022.
Congratulations to Patrick Laughlin on being awarded Graduate Fellowship
We are delighted to announce that graduate student, Patrick Laughlin, has been awarded a Quantitative Chemical Biology Graduate Fellowship.
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